Chemokine Nomenclature

Contents

Systematic Name Human Gene Alternate Human Names Human Receptor(s) Mouse Gene Alternate Mouse Names Mouse Receptor(s)

C Family
XCL1 XCL1 Lymphotactin, SCM-1 alpha, ATAC XCR1 Xcl1 Lymphotactin XCR1
XCL2 XCL2 SCM-1 beta XCR1      

CX3C Family
CX3CL1 CX3CL1 Fractalkine, Neurotactin, ABCD-3 CX3CR1 Cx3cl1 Fractalkine, Neurotactin CX3CR1

CC Family
CCL1 CCL1 I-309 CCR8, DARC Ccl1 TCA-3 CCR8
CCL2 CCL2 MCP-1, MCAF, HC11 CCR2, CCR4, CCR11, D6, DARC Ccl2 JE, MCP-1 CCR2, CCR4, D6, DARC
CCL3 CCL3 MIP-1 alpha, LD78 alpha, GOS19, Pat464 CCR1, CCR4, CCR5, D6 Ccl3 MIP-1 alpha CCR1, CCR4, CCR5, D6
CCL3L1 CCL3L1 LD78 beta CCR1, CCR3, CCR5, D6      
CCL3L3 CCL3L3 LD78 beta CCR1, CCR3, CCR5      
CCL4 CCL4 MIP-1 beta, AT744.1, ACT–2, G-26, HC21, H400, MAD-5, LAG-1 CCR1, CCR5, CCR8, D6 Ccl4 MIP-1 beta, AT744.1, ACT-2 CCR1, CCR5
CCL4L1 CCL4L1 AT744.2 CCR1, CCR5       
CCL4L2 CCL4L2   CCR1, CCR5      
CCL5 CCL5 RANTES CCR1, CCR3, CCR4, CCR5, D6, DARC Ccl5 RANTES CCR1, CCR3, CCR4, CCR5
CCL61 CCL23     Ccl6  C10, MRP-1 CCR1
CCL7 CCL7 MCP-3 CCR1, CCR2, CCR3, D6, DARC Ccl7 MARC, MCP-3 CCR1, CCR2, CCR3
CCL8 CCL8 MCP-2, HC14 CCR1, CCR2, CCR3, CCR5, CCR11, D6, DARC      
        Ccl82 MCP-2 CCR8
CCL9/103 CCL15     Ccl9 MIP-1 gamma, CCF18 CCR1, CCR3
CCL11 CCL11 Eotaxin CCR3, CCR5, D6, DARC Ccl11 Eotaxin CCR3, DARC
CCL12       Ccl12 MCP-5 CCR2
CCL13 CCL13 MCP-4, CK beta 10, NCC-1 CCR1, CCR2, CCR3, CCR5, CCR11, D6, DARC      
CCL14 CCL14 HCC-1, MCIF, CK beta 1, NCC-2 CCR1, CCR3, CCR5, D6, DARC      
CCL15 CCL15 MIP-1 delta, LKN-1, HCC-2, MIP-5, NCC-3 CCR1, CCR3 Ccl93 MIP-1 gamma, CCF18 CCR1, CCR3
CCL16 CCL16 HCC-4, LEC, ILINCK, NCC-4, LMC, CK beta 12 CCR1, CCR2, CCR5, CCR8, DARC, H4      
CCL17 CCL17 TARC, ABCD-2 CCR4, CCR8, D6, DARC Ccl17 TARC, ABCD-2 CCR4
CCL18 CCL18 PARC, DC-CK1, AMAC-1, CK beta 7, MIP-4 CCR8, PITPNM3, DARC      
CCL19 CCL19 MIP-3 beta, ELC, Exodus-3, CK beta 11 CCR7, CCR11, CCRL2/ CRAM A/B Ccl19 MIP-3 beta, ELC, Exodus-3, CK beta 11 CCR7, CCR11, CCRL2/LCCR
CCL20 CCL20 MIP-3 alpha, LARC, Exodus-1, ST38, CK beta 4 CCR6 Ccl20 MIP-3 alpha, LARC, Exodus-1, ST38, CK beta 4 CCR6
CCL21 CCL21 6Ckine, Exodus-2, SLC, TCA-4, CK beta 9 CCR7, CCR11  Ccl21a 6Ckine, Exodus-2, SLC, TCA-4, CK beta 9 CCR7, CCR11
        Ccl21b   CCR7
        Ccl21c   CCR7
CCL22 CCL22 MDC CCR4, D6 Ccl22 MDC, ABCD-1, DC/beta-CK CCR4
CCL23 CCL23 MPIF-1, CK beta 8, CK beta 8-1, MIP-3 CCR1, FPRL-1 Ccl61 C10, MRP-1 CCR1
CCL24 CCL24 Eotaxin-2, MPIF-2, CK beta 6 CCR3 Ccl24 Eotaxin-2, MPIF-2, CK beta 6 CCR3
CCL25 CCL25 TECK, CK beta 15 CCR9, CCR11 Ccl25 TECK, CK beta 15 CCR9, CCR11
CCL26 CCL26 Eotaxin-3, MIP-4 alpha, IMAC, TSC-1 CCR3, CX3CR1 Ccl264    
CCL27 CCL27 CTACK, ILC, PESKY, ESKINE CCR10 Ccl27a CTACK, ALP, ILC, PESKY, Eskine CCR10
        Ccl27b   Unknown
CCL28 CCL28 MEC CCR3, CCR10 Ccl28 MEC CCR10

CXC Family
CXCL1 CXCL1 GRO alpha, MGSA, GRO1, NAP-3 CXCR2, DARC Cxcl35 DCIP-1 CXCR2, DARC
CXCL2 CXCL2 GRO beta, MIP-2 alpha, GRO2 CXCR2, DARC Cxcl2 MIP-2 CXCR2, DARC
CXCL3 CXCL3 GRO gamma, MIP-2 beta, GRO3 CXCR2, DARC Cxcl15 KC CXCR2
CXCL4 PF4  PF4 CXCR3, CXCR3B, DARC      
CXCL4L1 PF4V1 PF4V1 CXCR3, CXCR3B Pf4 PF4 CXCR3
CXCL5 CXCL5 ENA-78 CXCR2, DARC      
CXCL6 CXCL6 GCP-2 CXCR1, CXCR2, DARC Cxcl56 LIX CXCR1, CXCR2, DARC
CXCL7 PPBP NAP-2, CTAPIII, beta-TG CXCR1, CXCR2 Ppbp NAP-2, CTAPIII, beta-TG CXCR1, CXCR2
CXCL8 IL-8 IL-8, NAP-1, MDNCF, GCP-1 CXCR1, CXCR2, DARC      
CXCL9 CXCL9 MIG, CRG-10 CXCR3, CXCR3B, DARC Cxcl9 MIG, CRG-10 CXCR3
CXCL10 CXCL10 IP-10 CXCR3, CXCR3B, DARC Cxcl10 CRG-2, IP-10 CXCR3
CXCL11 CXCL11 I-TAC, beta-R1, H174, IP-9 CXCR3, CXCR3B, CXCR7, DARC Cxcl11 I-TAC, beta-R1, H174, IP-9 CXCR3, CXCR7
CXCL12 CXCL12 SDF-1, PBSF CXCR4, CXCR7 Cxcl12 SDF-1, PBSF CXCR4, CXCR7
CXCL13 CXCL13 BCA-1, BLC CXCR3, CXCR5, DARC Cxcl13 BCA-1, BLC CXCR5
CXCL14 CXCL14 BRAK, BMAC Unknown Cxcl14 BRAK, BMAC Bolekine Unknown
CXCL15       Cxcl15 Lungkine, Weche Unknown
CXCL16 CXCL16 SR-PSOX CXCR6 Cxcl16 SR-PSOX CXCR6
CXCL17 CXCL17 DMC, VCC-1 Unknown Cxcl17 DMC, VCC-1 Unknown
LIX       Cxcl5  LIX6 CXCR1, CXCR2, DARC

NOTE: Alternate names shown in BOLD represent the most commonly recognized name. Receptors shown in BOLD are referenced in Zlotnik A. & O. Yoshie (2012). Additional studies have demonstrated chemokine ligand binding to additional chemokine receptor family members (See References). Those receptors are also included here but are not shown in bold.

Footnotes

  1. Following in-depth genome analysis, it has been determined that the gene product encoded by mouse Ccl6 is homologous to human CCL23.
  2. Mouse CCL8 is not the human CCL8 ortholog but is instead a mouse-specific chemokine.
  3. Mouse CCL9 was found to be equivalent to mouse CCL10. Additionally, following in-depth genome analysis, it has been determined that the gene product encoded by mouse Ccl9 is homologous to human CCL15.
  4. This gene is not expressed.
  5. Following in-depth genome analysis, it has been determined that the gene product encoded by mouse Cxcl3 is homologous to human CXCL1, and the gene product encoded by mouse Cxcl1 is homologous to human CXCL3.
  6. Zlotnik, A. & O. Yoshie (2012) suggests that following in-depth genome analysis, the gene product encoded by mouse Cxcl5 is homologous to human CXCL6. However, a consensus is emerging in the field that the mouse Cxcl5 gene encoding the LIX protein is a rodent-specific chemokine and does not have a pure human ortholog.

References

  1. Zlotnik, A. & O. Yoshie (2012) Immunity 36:705.
  2. Zlotnik, A. & O. Yoshie (2000) Immunity 12:121.
  3. Hansell, C.A. et al. (2011) Immunol. Cell Biol. 89:197.
  4. Gosling, J. et al. (2000) J. Immunol. 164:2851.
  5. Balkwill, F. (2004) Nat. Rev. Cancer 4:540.
  6. Schweickart, V.L. et al. (2000) J. Biol. Chem. 275:9550.
  7. Leick, M. et al. (2010) Immunology 129:536.
  8. Lasagni, L. et al. (2003) J. Exp. Med. 197:1537.
  9. Houshmand, P. & A. Zlotnik (2003) Curr. Opin. Chem. Biol. 7:457.
  10. Moore, B. et al. (2006) Am. J. Respir. Cell Mol. Biol. 35:175.
  11. Elsner, J. et al. (2005) Allergy 60:1386.
  12. Vandercappellen, J. et al. (2011) Cytokine Growth Factor Rev. 22:1.
  13. Howard, O.M.Z. et al. (2004) Biochem. Biophys. Res. Commun. 320:927.
  14. Struyf, S. et al. (2001) Eur. J. Immunol. 31:2170.
  15. Islam, S.A. et al. (2013) J. Exp. Med. 210:1889.